Team leader
Yukinori Okada
Objectives of the team
The genome analysis research team aims to elucidate the mechanisms underlying the onset and aggravation of infectious diseases from the perspective of genome analysis and identify factors that can contribute to the development of novel vaccines.
Description of research and development by the team
The team analyzes host genome information from symptomatic patients with infectious diseases and vaccinated individuals and compares it with the data from a control population to identify genes and novel targets that are involved in the acquisition of vaccine-induced immunity as well as the onset and aggravation of infectious diseases. The team decodes genome sequences of pathogens, such as bacteria and viruses, and integrates them with host genome sequences. Furthermore, this team combines state-of-the-art omics data, such as single-cell analysis of the host genome, to elucidate pathogenic mechanisms of infectious diseases as well as mechanisms of immune responses to vaccines and identify novel targets for vaccine development.
Tasks of the team
- 1Identification of host genomic factors involved in the onset of infectious diseases
- 2Identification of host genomic factors involved in the aggravation of infectious diseases
- 3Elucidation of interactions between the host and pathogen genomes in the pathogenesis of infectious diseases
- 4Elucidation of pathogenic mechanisms of infectious diseases and identification of factors contributing to vaccine development through statistical genetics by integrating the host genome, pathogen genomes, and omics data
- 5Training of young bioinformaticians
